Bacterial Invasion: Linking Autophagy and Innate Immunity
نویسندگان
چکیده
Crohn's disease is a chronic inflammatory bowel disorder that has been associated with polymorphisms in the genes encoding the pattern-recognition receptor NOD2 and the autophagic regulator ATG16L1. A new study demonstrates that NOD2 recruits ATG16L1 at bacterial entry sites, thereby bridging innate immunity and autophagy.
منابع مشابه
Nod proteins link bacterial sensing and autophagy.
Autophagy is one of the main cellular degradation systems in eukaryotes, responsible for the elimination of long-lived proteins and damaged organelles. Besides its well-documented role as a housekeeping mechanism, autophagy has recently caught the attention of groups working in the fields of microbiology and immunology, especially those working in innate immunity. In particular, the highly spec...
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Lorenzo Galluzzi, Oliver Kepp and Guido Kroemer* INSERM, U848 ‘Apoptosis, Cancer and Immunity’, Villejuif, France, Institut Gustave Roussy, Villejuif, France, Université Paris Sud-XI, Villejuif, France, Metabolomics Platform, Institut Gustave Roussy, Villejuif, France, Centre de Recherche des Cordeliers, Paris, France, Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France an...
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عنوان ژورنال:
- Current Biology
دوره 20 شماره
صفحات -
تاریخ انتشار 2010